L-glutathione (L-Glutathione) 600 mg

Glutathione is a powerful antioxidant and regulator of a number of biochemical processes. There is a lot of it in human tissues, but its amount decreases with age. Studies show that glutathione can help reduce neurodegenerative diseases, improve cartilage health, prevent age-related eye changes, improve immune function, and preserve youthful skin. In general, there is convincing evidence that glutathione is a powerful antiaging compound with extensive benefits for immunity and health. You can buy it in our online store.

L-glutathione

L-glutathione — it is a short peptide consisting only of cysteine, glutamate and glycine. It occurs naturally throughout the body and acts primarily as an antioxidant and auxiliary agent for a number of processes in the central nervous system. Glutathione is especially important in liver detoxification processes and as an absorber of free radicals in the brain. There is a lot of evidence that the loss of glutathione can contribute to the development of neurodegenerative diseases, such as Parkinson's disease, as well as eye diseases, such as cataracts and diabetic retinopathy.
Decreased glutathione levels are thought to be both a consequence of aging and a contributing factor to the aging process.
Chronic diseases also reduce glutathione levels

Oral intake of glutathione turns out to be ineffective due to the breakdown of the peptide in the gastrointestinal system. Although much attention is paid to oral supplements of glutathione precursors such as N-acetylcysteine ​​(NAC), studies show that glutathione levels tend to decline with age due to loss of production capacity (usually beginning in middle age). This loss of production capacity ultimately limits the effectiveness of NAC and other precursors for the production of glutathione. The best evidence indicates that glutathione is most effective when injected or inhaled through nasal preparations.

Glutathione is an antioxidant

L-glutathione has long been recognized as one of the most important low-molecular antioxidants synthesized by body cells. Thanks to the sulfur contained in the cysteine ​​component of GSH, it is able to remove powerful free radicals from the body, such as peroxides, nitrogen dioxide, NOS and many other toxins. It does this by means of the main oxidation-reduction reaction, thereby protecting cells, DNA and components of the extracellular matrix from damage caused by free radicals. Glutathione not only directly neutralizes free radicals, but also helps other antioxidants, such as vitamins C and E, to fulfill their role as antioxidants.

Glutathione is so important for the human body that its deficiency is associated with a wide range of diseases, such as diabetes, HIV, cancer and even tuberculosis. Studies show that the level of glutathione can be an important marker of the severity and progression of the disease. Measuring glutathione can offer doctors a more quantitative means of assessing prognosis and help determine the effectiveness and timing of various interventions. Despite the understanding of the role of glutathione in aging and diseases, routine methods of measuring and evaluating glutathione levels have not been established. Now researchers are studying how measuring this simple peptide can provide critical insight into everything from general health to the effectiveness of specific treatment methods. In the near future, measuring glutathione levels may become as common and useful as measuring blood pressure, cholesterol, and blood sugar.

Biological role of L-glutathione

Although glutathione is best known for its antioxidant functions, the peptide also plays other roles in the human body. This is an important and even necessary molecule for the production of leukotrienes (inflammatory mediators) and prostaglandins. This makes it a powerful regulator of certain immune reactions, as well as the inflammatory cascade. It is also a cofactor of a number of biochemical reactions and enhances the function of citrulline in the nitric oxide cycle.
In other words, glutathione is an important component of cellular metabolism and is especially important for regulating blood pressure and heart health.

• Glutathione is also crucial for the correct folding of proteins in the endoplasmic reticulum. Studies show that glutathione helps proteins fold into the correct three-dimensional form to bind to receptors and function normally. This is especially important when disulfide bonds are formed. Although it is not the only mechanism that cells use to ensure proper protein folding, glutathione is an important aspect of this cellular function and thus contributes greatly to the proper functioning of cells.

A note about glutathione administration

Research shows that glutathione is poorly absorbed from food sources or as a result of oral intake. It is believed that enzymes of the gastrointestinal tract can break it down into parts before it can be absorbed. There is some evidence that curcumin, N-acetylcysteine, and certain food components such as broccoli and spinach may help increase glutathione levels by providing more precursors for its synthesis or directly activating the synthesis process itself.

Unfortunately, there is a limited amount of evidence confirming that the above-mentioned options are the optimal way to increase glutathione levels. Although they increase the level of glutathione to some extent, the magnitude of their effect seems to be limited, primarily because they cannot overcome the decrease in the level of GSH caused by the loss of synthetic ability. Studies show that the only reliable way to significantly change glutathione levels — it is an injection of the peptide or its inhalation. Dr. Nayan Patel developed a system for transdermal delivery of glutathione, but it has not yet been widely distributed.

L-glutathione and the brain

Decreased glutathione levels are associated with common signs of aging, as well as with more serious disorders, such as neurodegenerative diseases. In particular, glutathione pathology plays a significant and possibly decisive role in the development of Parkinson's disease (PD). A new study shows that glutathione is a powerful mediator of a process called iron-dependent cell death, or ferroptosis. Without glutathione, this type of programmed cell death occurs uncontrollably in the cells of the central nervous system, causing premature aging and contributing to the development of neurodegenerative diseases. Numerous studies show that supplements with glutathione or its precursors (for example, N-acetylcysteine) are especially useful for compensating for neurological aging.

Glutathione's role in the brain also becomes apparent due to the decline in glutathione levels with age. Research shows that although the level of glutathione decreases with age throughout the body as a result of a decrease in the ability to produce it, its level decreases most sharply in the brain.
This makes the brain more susceptible to both Parkinson's disease and damage after a stroke or second stroke.

Decreasing the level of glutathione in the brain is especially critical during stress.
Mild stress usually causes an increase in the production of glutathione to protect against more serious stress, but the decrease in synthetic ability with age destroys this reaction. Thus, the older we get, the more susceptible we are to stress-induced neuronal damage. Compensation for this with the help of N-acetylcysteine ​​supplements is only partially effective, since the synthetic mechanism itself is at risk with age. Thus, studies show that direct injection (or inhalation) of glutathione is the best way to increase levels of this antioxidant and prevent stress-related damage to the central nervous system.

Brief description of L-glutathione

lutathion is a powerful antioxidant and regulator of a number of biochemical processes. There is a lot of it in human tissues, but its amount decreases with age.
Research shows that glutathione can help reduce neurodegenerative diseases, improve cartilage health, prevent age-related eye changes, improve immune function, and preserve skin youth. Overall, there is strong evidence that glutathione is a powerful antiaging compound with extensive immune and health benefits.

Glutathione exhibits minimal side effects, low oral bioavailability and excellent subcutaneous bioavailability in mice. The dosage per kg for mice does not apply to humans. The sale of glutathione at Peptide Sciences is limited to educational and scientific research and not for human consumption. Buy glutathione only if you are a licensed researcher.