IGF-2 peptides (IGF-2) 1 mg

IGF-2 (insulin-like growth factor-2)

IGF-2 is a member of the insulin growth factor family of polypeptides that are involved in development and growth. It is an imprinted gene and is expressed only from the paternal hereditary allele. It is a candidate gene for eating disorders. There is an INS-IGF2 reader that aligns with this gene in the 3' region and with the ascending INS gene in the 5' region. For of this gene, two alternatively spliced ​​transcript variants encoding the same protein were found.

Insulin-like growth factor II, also known as IGF-II, somatomedin-A, and IGF2, is a secreted protein that belongs to the insulin family. The insulin family, consisting of insulin, relaxin, insulin-like growth factors I and II (IGF-I and IGF-II), and possibly the beta subunit of nerve growth factor 7S, is a group of structurally related polypeptides, the biological functions of which differed. IGFs, or somatomedins, make up a class of polypeptides that play a key role in the growth of mammals up to adolescence. IGFs have the ability to stimulate growth.

They are powerful mitogens for cultured cells. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF2 / IGF-II is perhaps the most complexly regulated of all growth factors characterized to date. Activity of IGF2 / IGF-II controlled by the differential expression of receptors and IGF-binding proteins (IGFBPs), which determine protein availability. IGF2 / IGF-II is influenced by placental lactogen, which can play a role in fetal development. Genetic variations in IGF2 are associated with body mass index (BMI). BMI is a statistical measurement that compares a person's weight and height.