N-Acetyl Selank Amidate (N-Acetyl Selank Amidate) 10 mg

N-Acetyl Selank Amidate is best viewed as an improved version of Selank. Studies have shown that
N-acetyl selanic amidate improves all aspects of selanic, increasing its effectiveness, half-life, absorbability and the ease with which it overcomes the blood-brain barrier. These properties help to enhance the action of the peasant, which, as it was found in animal studies, protects the central nervous system from diseases and injuries, reduces anxiety, improves learning, improves memory and changes the blood clotting process. Although additional research remains to be done, Selank and other glyprolins offer insight into how DNA expression patterns can be altered by a single peptide, leading to dramatic effects. You can buy it in our online store

N-Acetyl Selank Amidate

N-acetyl selank amidate is a modified form of selank peptide. Selank is a short nootropic and anxiolytic peptide originally developed in Russia. This is an analogue of natural tafcin, which has an immunomodulating effect. Studies show that Selank changes the expression of genes in the brain, reducing the effect of the neurotransmitter GABA, changing the permeability of cell membranes and increasing the production of brain-derived neurotrophic factor (BDNF).

The modified form of selan, N-acetyl selan amidate, has a longer half-life and greater ability to overcome the blood-brain barrier. It also has stronger binding to receptors due to amidation. Selank is currently being studied in animal models for the treatment of stroke and other ischemic brain diseases. It is also considered as a means of treating generalized anxiety disorder and memory protection in neurodegenerative diseases.

N-acetylselanc amidate and DNA

Selank and anxiety

Perhaps the most thoroughly and carefully studied property of Selanka is its ability to modulate anxiety. Research shows that Selank has clinical effects similar to those of drugs such as benzodiazepines used to treat serious anxiety disorders.
Selank has been shown to effectively reduce anxiety, reduce stress, and improve mood. It appears that it does this by interacting (probably indirectly) with the GABA d receptor, as benzodiazepines do. It even has a similar sedative effect compared to benzodiazepines.

However, Selank differs from such drugs as Ativan and Valium in that it is not addictive. Benzodiazepines have a well-known abuse potential and can cause physical dependence or even addiction. Selanc does not appear to have this problem and, in fact, may be useful in helping those addicted to benzodiazepines safely and effectively wean them off.

Studies show that out of 84 genes related to GABA, Selank modifies at least 45 of them. As noted above, the effect of Selank on the GABA receptor is most likely indirect. Instead of binding to the GABA receptor, Selank is thought to change the affinity of the receptor for its natural ligand and thus help reduce anxiety by reducing the effect, but not the concentration, of natural GABA.

It is interesting that Selank and traditional benzodiazepines were tested in combination. Using both appears to be more effective in treating certain types of anxiety than using either one alone. In particular, this combination turns out to be very useful in the treatment of an often resistant form of anxiety known as unpredictable chronic mild stress.

Selanc and the blood-brain barrier

Selanc is a member of the family of peptides known as glyprolins.
Glyprolins are well known for their regulatory functions in biological systems. In particular, it is known that glyprolins have a protective and restorative effect on the entire body. Where their effects are manifested depends on the amino acid sequence of a particular glycoprotein.

Some of them are active in the gastrointestinal tract or pancreas, while others, such as Selank, are active in the central nervous system.

In the whole family of glyprolines, they were neglected in research. However, some features common to these highly stable oligopeptides were identified.
Perhaps the most important in the case of the peasant is the ability of glyprolins to penetrate the blood-brain barrier. Hematoencephalic barrier
(HEB) is a powerful combination of cellular and extracellular components that limit the entry of substances from the general circulation into the central nervous system. Glyprolins penetrate this barrier more easily than most other oligopeptides.

N-acetylselanc amidate and the immune system

According to Dr. Olga Uchakina (recipient of a grant from the Mercer University School of Medicine and the Rockefeller Foundation), it was shown in animal studies that selanc suppresses the production of the inflammatory cytokine IL-6[4]. L-6 (interleukin-6) is secreted by macrophages, as well as cells of the bone marrow and blood vessels. This is an inflammatory marker of severe infection with COVID-19. IL-6 is an important mediator of fever, neutrophil production, and B-cell growth. In the central nervous system, IL-6 plays a role in the consolidation of emotional memories associated with sleep, and may play an important role as a mediator of pain perception.

It is he who is the mediator of pain perception and is of particular interest to researchers studying the interaction of IL-6 and the peasant. Studies on rats show that Selank can modulate the expression of IL-6 in the central nervous system and, therefore, can help reduce pain in so-called asthenic symptoms. The medical community has long debated whether there is a connection between mental illness and physical pain. The ability of Selanka to alleviate physical pain in psychiatric diseases seems to indicate the accuracy of the hypothesis and at the same time offers a solution. At present, it is not clear whether Selank can relieve other types of neurogenic pain. Future research may help uncover the role of glyprolins as regulators of pain generated by the nervous system, and thus help scientists better understand how to treat and control neuropathic pain.

The purpose of amidation

Amidation — another minor modification of the peptide, this time the carboxyl group at the other end of the amino acid chain. Like N-acetylation, amidation is a natural process that occurs in approximately half of all known peptides. Amidation makes peptides less sensitive to proteolytic cleavage and prolongs their half-life in the bloodstream. Amidated peptides are less sensitive to pH changes and more easily bind to their receptors. They also bind more firmly to their target receptors, which extends the action of amidated proteins compared to their non-amidated counterparts.
Oxytocin, thyroid-releasing hormone, and vasopressin are natural peptides whose amidation is known to significantly enhance biological activity.

N-acetylselanc amidate: Summary

N-acetyl selank amidate is best viewed as an improved version of selank. N-acetyl selanic amidate improves all aspects of selanic, increasing its effectiveness, half-life, absorbability, and the ease with which it crosses the blood-brain barrier. These properties help to enhance the action of the peasant, which, as it was found in animal studies, protects the central nervous system from diseases and injuries, reduces anxiety, improves learning, improves memory and changes the blood clotting process. Although additional research remains to be done, Selank and other glyprolins offer insight into how DNA expression patterns can be altered by a single peptide, leading to dramatic effects.