GHRH (growth hormone releasing hormone) peptide
Growth hormone-releasing hormone is commonly called GRF (growth hormone-releasing factor) or GHRH 1-44, because it is a peptide of 44 amino acids. Studies have shown that in most species GRF (1-44) stimulates the release and synthesis of growth hormone. GRF is synthesized by neurons in the arcuate nucleus of the hypothalamus. After entering the portal the circulation of the pituitary gland it stimulates the release of growth hormone by somatotrophs in the pituitary gland. Endogenous GHRH (1-44) has a very short active life, but is released from the hypothalamus before traveling a very short distance to the anterior lobe of the pituitary gland, where GH is released. In contrast, exogenous peptides are usually delivered exogenously through one of several types of injections, and must circulate before reaching the pituitary gland and activation of cells that store and release GH, called somatotrophs. Studies have shown that GHRH helps stimulate the release and synthesis of growth hormone. Studies have also shown that it promotes slow-wave sleep. GHRH is synthesized by neurons in the arcuate nucleus of the hypothalamus. GHRH stimulates the production and release of GH by binding to GRFR, the GHRH receptor on cells.
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