Kisspeptin-10 (Kisspeptin-10) 5 mg

Kisspeptin controls the secretion of hormones related to reproduction. Kisseptin can affect testosterone levels and sexual behavior, such as attraction and motivation. Studies also show that it can help reverse some of the effects of aging. You can buy it in our online store.

What is kisspeptin-10

Kisspeptin (also known as metastin) — This is a natural human protein that plays an important role in the transmission of hormonal signals during pod maturation and reproduction. It is also believed to change mood and behavior, promote angiogenesis, and regulate kidney function. The peptide has also been found in the brain and is known to suppress tumor growth and metastasis (spread).
The peptide is of greatest scientific interest due to its ability to affect gonadotropin-releasing hormone (GnRH).

Studies of kisseptin-10

Increase in the level of gonadotropin-releasing hormone

Gonadotropin-releasing hormone (GnRH) is synthesized and released from
GnRH neurons of the hypothalamus. This is the first hormone released in the hypothalamus-pituitary-gonadal axis, which controls the release of follicle-stimulating hormone (FSH) and luteinizing hormone
(LH) in the anterior lobes of the pituitary gland. GnRH is the main factor in sexual maturation and controls the maturation of gametes in the genital organs. In some cases, it is used therapeutically to control menstruation, to treat premature puberty, and as a continuous infusion for some types of cancer.

Increased testosterone level

Influencing circulating levels of LH and FSH, kisspeptin can alter testosterone levels. However, this change seems to depend on gender.
In men, kisspeptin increases testosterone levels, while in women it does not have a noticeable effect on testosterone levels. In one study, 6 men were injected with a kisspeptin derivative intravenously.
They showed a significant increase in plasma testosterone levels (almost 3 times) after only 90 minutes. It was found that the second analogue of kisspeptin changes the frequency of LH pulsation in men, which suggests that kisspeptin helps to fine-tune the normal pulsatile release of sex hormones. A study of healthy men taking kisspeptin-10 revealed a rapid and dose-dependent increase in the level of LH in the blood serum and a concomitant increase in the level of testosterone. Kisspeptin-10 apparently achieves this effect by increasing the pulsatile release of LH. When taken in sufficiently high doses, kisspeptin-10 causes such a rapid pulsation that it completely hides individual pulses, which leads to continuous release of LH. This discovery opens the door to the potential use of kisspeptin and its analogues in various situations: from pregnancy to low testosterone and many others

Energy balance

It has long been known that kisspeptin neurons are sensitive to the energy status of a person. Both insufficient and severe overeating can blunt the action of kisspeptin neurons to stimulate the release of GNRH. In fact, drastic changes in energy balance can lead to infertility in both men and women, and this process appears to be mediated by kisspeptin.

So, it is well known that production and release of kisspeptin is sensitive to energy balance. However, it becomes clearer that kisspeptin itself can regulate the energy balance. This discovery was the result of observing mice in which the kisspeptin receptor (Kiss 1g) was removed through genetic manipulation. Increased obesity and decreased energy expenditure were observed in these mice.
It turns out that the kisspeptin receptor is found in adipose (adipose) tissue and brown adipose tissue. It is not surprising that kisspeptin plays a role in energy balance, since energy status and reproductive capacity have always been closely related. It seems that kisspeptin may be one of the links helping to explain the neurochemical control that leads to energetic modulation of reproductive behavior.

The study of memory improvement

It seems that some analogs of kisspeptin play an important role in brain regions responsible for memory consolidation and orientation in three-dimensional space. Studies on mice show that the introduction of these peptides can help reverse learning and navigation disorders often observed in ethanol intoxication. This suggests that kisspeptin and its analogues play a role in the ability of neurons to encode information and can make these peptides potentially interesting for compensating the learning deficit observed in certain genetic and chronic diseases. Although this research is in its early stages, it will help expand our understanding of learning and push us toward the development of nootropics that can help stimulate both healthy and damaged brains to improve brain function.

Influence on mood

Just as reproduction and energy status are interconnected, reproduction and emotions are also interconnected. Given the role of kisspeptin both in reproduction and in energy homeostasis, researchers wondered how the peptide could influence emotions and behavior. To test this connection, they compared kisspeptin with a placebo in 29 healthy heterosexual men. increased activity of the limbic system of the brain was observed in persons taking kisspeptin. In particular, people demonstrated increased reward-seeking behavior, increased drive, and improved general mood. It seems that kisspeptin plays a role in the integration of sexual and emotional processes of the brain in the general process of reproduction. These results help to deepen our understanding of moods, motivations, and drives, not only in the sense that they are related to sex, but also in terms of human behavior in general

Kisseptin-10 Summary

Kisspeptin — This is a peptide that acts primarily, but not exclusively, in the brain, controlling the secretion of hormones related to human reproduction. There is great interest in understanding how kisspeptin affects everything from testosterone levels to sexual behavior, such as desire and motivation.

For many years, it was also understood that kisspeptin could potentially affect the growth and metastasis of cancer cells. However, the studies were somewhat contradictory, which led to periods of growth and decline in interest in the use of kisspeptin as a treatment in chemotherapy regimens. The peptide's ability to influence metastasis may be related to its role in the growth and functioning of blood vessels. Kisspeptin is currently the subject of a number of intensive trials aimed at deepening our understanding of this universal and potentially life-saving peptide.

Kisspeptin-10 exhibits minimal to moderate side effects, moderate oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage per kg for mice does not apply to humans. Kisseptin-10, sold by Peptide Sciences, is intended only for educational and scientific research, and not for human consumption. Buy Kisseptin-10 only if you are a licensed researcher.