Cortagen (Cortagen) bioregulator 20 mg

Cortagen — bioregulatory peptide with a primary effect on the brain and central nervous system. You can buy it in our online store. It has a secondary effect on the immune system and heart tissue. Studies show that it is a powerful regulator of the inflammatory response, especially in the nervous system, helping to restore balance and proper functioning between pro- and antioxidant processes. It was studied as a potential treatment after ischemic brain damage, where it and similar compounds showed positive long-term results. Cortegen stimulates the expression of interleukin-2 and helps regulate immune function, primarily by reducing autoimmune reactions.

Cortagen (Ala-Glu-Asp-Pro) — one of the many "Havinson's peptides". These short peptides (often consisting of only 2-4 amino acids) have powerful bioregulatory functions and often change the pattern of gene expression in tissue-specific patterns. Discovered by Vladimir Khavinson, Kortagen acts primarily on the central nervous system with secondary effects on the heart and immune system.
Research shows that Kortagen stabilizes the inflammatory reaction in the central nervous system, helping to maintain a balance between pro- and anti-inflammatory pathways. Animal studies have shown that it reduces the long-term consequences of ischemic brain damage and helps restore nerve function after a cut or injury. Cortegen is a geroprotective and antiaging peptide. This helps to return DNA to a younger state, which reduces aging and increases the expression of certain genes that are often silenced with age

Cortagen and aging

Research shows that patterns of gene expression change with age. In particular, gene expression levels generally tend to fall as DNA condenses from a more open form of euchromatin into a more densely packed form called heterochromatin. This condensation process prevents the access of DNA transcription factors to certain genes and is one of the main factors contributing to the aging process (such as cellular aging). Studies show that peptide bioregulators can help reverse condensation and return cells to a more youthful state.

Cortagen has a pronounced effect on both structural and functional aspects of peripheral nerves, as well as cardiac tissue. It was believed that this probably arose as a result of decondensation of chromatin structures. Scientists tested this hypothesis using microarray analysis of the transcriptome and found significant changes in 110 known genes scattered over more than 234 different regions of DNA

In another experiment with similar goals, it was found that
Cortagen increases the activity of ribosome genes and unpacks chromatin fibrils in such a way that genes repressed as a result of age-related chromatin condensation are released. Similar DNA decondensation is observed in other bioregulatory peptides, and each peptide has a tissue-specific effect and has an insignificant amount of off-target effects .

In addition to changing the structure of DNA and reactivating dormant genes, Cortegen also affects aging by strengthening the body's natural antioxidant mechanisms. Studies on rats show that Kortagen reduces the level of lipid peroxidation products. This reduces the amount of proteins subject to pathological oxidation processes and suppresses antioxidant activity both in the blood and in the brain. Peroxidation of lipids (POL) — this is a form of tissue damage mediated by free radicals, which especially affects cell membranes in tissues with a high level of lipids.
Lipids are abundant in the central nervous system, where they insulate the nerve. Oxidation of these lipids can lead to a decrease in nerve conduction and contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

Cortagen and nerve regeneration

Studies on rats show that an intramuscular injection of cortagen at a dose of 10 μg/kg can increase the regeneration of nerve fibers in a severed arc up to 40%. This study suggests that surgical repair of a damaged nerve followed by cortagen injection may actually help stimulate nerve repair and improve outcomes after severe spinal cord injury. This mechanism of action is probably similar to the recovery mechanism of 20 mg Cortegen in the brain. It has long been known that the balance between pro- and anti-inflammatory conditions promotes the healing of other tissues, so it seems reasonable to assume that it has the same beneficial effect on the central nervous system.

Brief description of Kortagen

Kortagen — bioregulatory peptide with a primary effect on the brain and central nervous system. It has a secondary effect on the immune system and heart tissue. Studies show that it is a powerful regulator of the inflammatory response, especially in the nervous system, helping to restore balance and proper functioning between pro- and antioxidant processes. It was studied as a potential treatment after ischemic brain damage, where it and similar compounds showed positive long-term results. Cortegen stimulates the expression of interleukin-2 and helps regulate immune function, primarily by reducing autoimmune reactions.