KPV 5 mg

KPV — a powerful anti-inflammatory peptide that has shown promising efficacy in a number of diseases. The most active research is conducted in the field of treatment of inflammatory bowel diseases, where the peptide has shown significant prospects. Animal studies have shown that KPV is safe and effective when administered orally, intravenously, subcutaneously, and transdermally. Wound healing studies also show that KPV and other alpha MSG derivatives may have multiple benefits that accelerate wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV and similar peptides can become the basis not only of wound healing, but also of reducing scars after surgery. You can buy it in our online store.

CPV (ACTH(11-13), alpha-MSH)

KPV is a C-terminal peptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). This is one of many short peptide derivatives of alpha-MSG that have been tested to determine whether they retain similar photoprotective properties, activity against ischemia, sexual effects, or influence on eating behavior and energy homeostasis. KPV, consisting of lysine-proline-valine, has a significant anti-inflammatory effect. The peptide is in the stage of active research as a potential therapeutic agent in the treatment of inflammatory bowel diseases. It has demonstrated powerful anti-inflammatory activity in the central nervous system, gastrointestinal tract, lungs, vascular system, and joints. Since KPV is a small peptide, it can be administered in several ways, including oral, intravenous, and transdermal routes.

KPV Research

Intestinal inflammation

Perhaps the most important discovery made as a result of KPV studies is that the peptide reduces intestinal inflammation. In mouse models of inflammatory bowel disease (IBD), KPV shows promising results, reducing inflammatory infiltrates, MPO activity and general histological signs of inflammation. Mice receiving CPV in the study recovered faster and had a more pronounced weight gain than mice receiving a placebo.

Further studies of the mechanisms of KPV delivery have shown that loading KPV into anoparticles functionalized with hyaluronic acid helps to direct the inflammatory effects of the peptide to the right places in the intestine. This leads to accelerated healing of the mucous membrane and relief of inflammation due to effective suppression of TNF-alpha in mouse models. In many respects
‹PV is a more effective and more targeted means of reducing inflammation in IBD, without affecting TNF-alpha in other parts of the body.
The advantage of KPV modification is to improve the bioavailability of the peptide when taken orally. This does not increase the effectiveness of the peptide, but affects the effectiveness, so the total dose is required to achieve the effect.

Studies show that TNF-alpha — not the only mediator of inflammation that is affected by CPV. The peptide also reduces the activity of NF-kappaB and mitogen-activated protein kinase. These effects work in tandem with TNF-alpha inhibition, reducing inflammatory changes in the intestine. Mice receiving KPV had significantly less colonic infiltration and normal colonic length compared to the control group.

CPV as a general anti-inflammatory agent

Back in 1984, studies on rabbits showed that KPV is a powerful anti-inflammatory and antipyretic (antipyretic) agent.
However, in this case, KPV had a lower effectiveness than the complete alpha-MSH molecule. This allowed the scientists of that time to assume that some part of the alpha-MSG molecule, which is necessary for full antipyretic activity, is missing in the KPV. This was followed by decades of research into various modified forms of alpha-MSG.

Perhaps the biggest lesson learned from these trials is that alpha-MSG and some of its analogs reduce inflammation in a wide variety of diseases.
So far, the molecules have been tested for fever, irritant and allergic contact dermatitis, vasculitis, fibrosis, arthritis, and inflammation of the eyes, brain, lungs, and gastrointestinal tract.
In all cases, alpha-MSG is the most effective anti-inflammatory means Unfortunately, it has one serious side effect - it causes skin pigmentation. KPV does not have such a side effect. And although KPV is not as effective as intact alpha-MSH, its lack of side effects means that increasing the level to achieve the desired target effects is theoretically possible in most cases.

It was found that the difference in effectiveness is minimal at best, since most of the anti-inflammatory effects of alpha-MSG are actually due to the KPV section. However, it is interesting that the initial molecule seems to better suppress the inflammatory reaction at a late stage. For example, in the case of contact dermatitis, alpha-MSG better prevents an allergic inflammatory reaction 2 weeks after the initial exposure. This suggests that alpha-msg may affect some aspects of immune modulation other than the immediate inflammatory response. The work to determine what kind of process it is is still underway.

Summary of KPV

CPV — a powerful anti-inflammatory peptide that has shown promising efficacy in a number of diseases. The most active research is conducted in the field of treatment of inflammatory bowel diseases, where the peptide has shown significant prospects. Animal studies have shown that KPV is safe and effective when administered orally, intravenously, subcutaneously, and intravenously. Wound healing studies also show that KPV and other alpha MSG derivatives may have multiple benefits that accelerate wound healing, reduce infection, fight inflammation, and lead to better cosmetic results. KPV and similar peptides can become the basis not only of wound healing, but also of reducing scars after operations.

KPV shows minimal side effects, low oral bioavailability and excellent subcutaneous bioavailability in mice. The dosage per kg for mice does not apply to humans. KPV sold by Peptide Sciences is intended for educational and scientific research only and not for human consumption. Buy KPV only if you are a licensed researcher.